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Fatigued and Feel Like You Have Tried Everything?
You may be making a mistake by not knowing about DSIP: The Sleep Peptide
DSIP: This Simple Peptide Can Change Fatigue Symptoms For Good! Learn:
- The type of sleep that DSIP promotes and how this can help you with tissue repair, bone growth and immune system support
- How this peptide can help with various types of sleep, so that you can tailor the use of DSIP to specific needs
- Uses of DSIP for symptoms beyond sleep such as high blood pressure, giving you additional treatment options with less side effects than drugs
Are your patients or clients ALWAYS tired? Do they have problems sleeping? Or maybe it’s you who is often tired and dragging? Then meet a peptide called Delta Sleep Inducing Peptide. That’s a bit of a mouthful so we’ll just call it DSIP. Like other peptides, it can provide a novel remedy to health issues. DSIP is especially great for sleep and sleep issues. Please read on for the details!
** Please note: If you want the short summary version of this article, then please click here **
We have recently written many blogs about peptides. To recap, a peptide is a small protein, made up of a chain of amino acids. They can be used therapeutically to help with different health conditions. Click on the links to see our articles on peptide therapy, HGH, CJC 1295/Ipamorelin, BPC 157, PT 141, Ta1, VIP, Thymosin Beta 4, KPV, Trio and SS-31.
Sleep disturbances can be pretty common in today’s world. In our online functional medicine school (mindbodyfunctionalmedicine.com), we spend time teaching the topic of sleep and how to resolve the different sleep disturbances people experience. So we’re happy to present another tool in the toolbox for restoring people back to good sleep quality: DSIP!
DSIP Promotes Sleep
DSIP promotes a particular type of sleep, characterized by a rise in the delta rhythm of an EEG (Pollard BJ, 2001). Brain waves during sleep can be recorded with an EEG test. A delta rhythm is a pattern of slow brain waves usually associated with the deep stage 3 of NREM (non-rapid eye movement) sleep. This stage is also known as slow-wave sleep.
NREM sleep is dreamless sleep. It is associated with the brain restoring its supply of ATP (or cellular energy). During the deep stages of NREM sleep, the body repairs tissues, builds bone and muscle and strengthens the immune system. As we age, we sleep more lightly and get less deep sleep.
DSIP’s sleep-enhancing properties have been proven in rabbits, mice, rats, cats and humans (Pollard BJ, 2001).
DSIP is a peptide made in the hypothalamus of the brain (Pollard BJ, 2001). It has been found in the hypothalamus, pituitary, peripheral organs, tissues and body fluids (Charnay Y, 1989). A DSIP-like molecule has also been found in breast milk (Graf MV, 1984).
Found in small amounts in the blood, the concentration of plasma DSIP follows a diurnal or daily pattern and the circadian rhythm of the body (Pollard BJ, 2001). DSIP concentrations are low in the mornings and higher in the afternoons (Friedman TC, 1994). DSIP stimulates melatonin and serotonin synthesis and release in rat pineal glands (Ouichou A, 1992). Melatonin is also closely involved in the circadian rhythm or sleep-wake pattern of the body.
DSIP is not like a night-time sedative drug to be taken before bed. A dose of DSIP given during the day will promote improved sleep on the next night and for several nights thereafter (Friedman TC, 1994).
What does the Research say on DSIP?
Like functional medicine, our online functional medicine course is very research-focused. We pride ourselves on presenting the latest medical research to you. There is a lot of research out there on insomnia and sleep disturbances. We have gone through it all and are extremely well-equipped to teach you about people’s sleep issues and how to address and treat them.
Various studies have looked at DSIP and found somewhat inconsistent results (Pollard BJ, 2001). But what is consistent in the research is that DSIP promotes sleep (Friedman TC, 1994). DSIP increases the ‘pressure to sleep’ in people injected with small doses (Friedman TC, 1994). It has a modulating effect on sleep and wake functions. It works better in situations where sleep is already disturbed. It has less effect on people who are not already experiencing insomnia or sleep disturbances.
One study looked at a small group of chronic insomniacs (Schneider-Helmert D, 1981). They were given DSIP intravenously. The results showed longer sleep duration, a higher quality of sleep with fewer interruptions and slightly more REM sleep. They did not experience daytime fatigue or other side effects. The study shows DSIP’s normalizing influence on sleep regulation (Schneider-Helmert D, 1981).
In another controlled double-blind study, DSIP normalized disturbed sleep (Vgontzas AN, 1995). During awake cycles, better performance and increased alertness were seen, with improved stress tolerance and coping behavior (Sudakov KV, 1995). Coping better with stress is likely due to being well-rested and so better able to handle any stress.
For example, sleep loss at high altitude can worsen certain neurological functions, like attention, memory and decision making. A daily DSIP injection in rats at high altitude enhanced both their NREM sleep and REM sleep (Roy K, 2018). It also improved cognitive performance in the rats (Roy K, 2018). Better sleep quality as a result of taking DSIP restored spatial memory in rats at simulated high altitude circumstances (Roy K, 2018).
DSIP also leads to a significant reduction in stress in rats (Khvatova EM, 2003). Treatment with DSIP showed that it improves the efficiency of oxidative phosphorylation (the process by which ATP is formed in mitochondria). DSIP is therefore thought to have significant stress protective and antioxidant properties (Khvatova EM, 2003).
Other Benefits of DSIP Include:
Treating and reducing symptoms of alcohol and opioid withdrawal in some cases: Symptoms and signs of withdrawal disappear after a DSIP injection (Backmund M, 1998). In one trial, 97% of opiate-dependent and 87% of alcohol-dependent patients had less symptoms after taking DSIP (Backmund M, 1998).
An antihypertensive (blood pressure-lowering) effect: Hypertensive rats who took DSIP for 10 days had reduced blood pressure (Pollard BJ, 2001).
An anti-carcinogenic or anti–cancer effect: Mice treated with a preparation containing DSIP experienced significantly decreased tumor incidence by 2.6-fold, as compared to mice in the control group (Popovich IG, 2003).
Anti-aging effects: This same study on mice found some anti-aging properties (Popovich IG, 2003). DSIP slowed the age-related changes and reduction in the reproductive cycle of mice (Popovich IG, 2003). It decreased the frequency of chromosome aberrations in bone marrow cells by 22.6% (Popovich IG, 2003). Chromosome aberrations or abnormalities can occur as a result of aging and lead to cell death and disease. Taking DSIP also increased maximum life span in mice by 24.1%, in comparison with the control group (Popovich IG, 2003).
DSIP may reduce hyperthermia (Pollard BJ, 2001).
DSIP may be beneficial in some chronic pain conditions (Pollard BJ, 2001).
Antioxidant effects: DSIP improves the efficiency of oxidative phosphorylation (or ATP synthesis) in rat mitochondria in vitro, suggesting it may be a potent antioxidant (Khvatova EM, 2003).
Does DSIP have any Side Effects?
As DSIP is naturally occurring, side-effects are uncommon (Pollard BJ, 2001). Normally, DSIP concentrations in the body are quite low so an injection of a large non-physiological dose might be expected to lead to adverse effects. However, no significant side-effects have been reported with DSIP (Pollard BJ, 2001). In some people, an occasional headache, nausea or vertigo have been reported but these are only temporary. DSIP actually appears to be incredibly safe (Pollard BJ, 2001). In experiments, it has also been safe on animals at any dose administered (Pollard BJ, 2001).
No Time? => No Problem!
Here's the Summary of our Blog on DSIP:
- Peptide theory is a novel and safe approach to health issues
- DSIP is a peptide that promotes sleep in people experiencing insomnia and sleep disturbances
- DSIP works best in people with sleep disturbances, than in those who already sleep well
- DSIP has other health benefits including reducing withdrawal symptoms from alcohol or opiate abuse, anti-hypertensive, anti-cancer and anti-aging effects
- DSIP is safe to take and has no adverse effects
- Insomnia may have many causes including adrenal problems, melatonin imbalances, MSH deficiencies, babesia, mycotoxin illness, nutrient imbalances and more. Want to help your clients get to the root cause of their sleep issues and have a greater impact on their lives? Learn more about studying with us at our functional medicine school here: mindbodyfunctionalmedicine.com
**Please stay tuned for our next blog on more Peptide Therapy!**
As always, please get in touch with us. If you or someone you know is struggling with sleep disturbances, insomnia or general health issues, contact our clinic today. If you are interested in functional medicine training, please schedule a free practice evaluation call with us to see if our online functional medicine training and mentorship program meets your needs.
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