Alzheimer’s Disease: Positive Impacts of Diet and Lifestyle

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Alzheimer’s Disease: Positive Impacts of Diet and Lifestyle

In this blog, we will look at cognitive impairment & Alzheimer’s Disease in relation to various lifestyle factors. You will learn:

How lifestyle can affect your clients’ cognitive health
Which lifestyle factors can influence cognitive impairment & Alzheimer’s Disease
How to address and help clients with cognitive impairment, dementia or Alzheimer’s

Do you know what cognitive impairment is and how it can affect your clients? If you want to know more about this rapidly growing health concern and how to best optimize the health of your clients, then this blog is for you. Please read on for answers!

Do you get stuck clinically with chronic symptoms in your patients? Would you like to have a larger impact on improving your clients’ issues?

The key to optimal health is an individual approach using nutrition, lifestyle and exercise. To improve your patients’ quality of life, you need to identify and address the root causes. Our functional medicine course will teach you how to do this. Look into our functional medicine school to have a greater impact on improving your client’s lives.

** Please note: If you want the short summary version of this article click here. **

What is Alzheimer’s Disease (AD)?

Alzheimer’s Disease is a brain disorder that slowly destroys memory and thinking skills. Symptoms include memory loss, language problems, unpredictable behavior, and, as it progresses, the ability to carry out the simplest tasks. In most people, symptoms first appear in their mid-60s (National Institute on Aging, 2021). You can read about Alzheimer’s in our blog here.

Alzheimer’s Disease Facts:

Alzheimer’s Disease is the most common cause of dementia among older adults (National Insitute on Aging, 2021).
AD is estimated to be the 3rd leading cause of death (Toups K, 2022).
Approx. 6 million people in the US have Alzheimer’s Disease (Toups K, 2022).
Alzheimer’s Disease accounts for almost 70% of all dementia cases (Seaks CE, 2020).
Your lifetime risk of developing AD is approximately 15%, assuming no prevention (Bredesen, 2016).
AD and dementia can lead to degeneration of cells in the brain and neuroinflammation.
AD and dementia are caused by interactions between genes and the environment. Multiple factors cause cognitive decline, such as increasing age, genetic factors, head injuries, vascular diseases, infections and lifestyle & environmental factors (Breijyeh Z, 2020).
Therapeutic approaches to date have not led to sustainable improvements. The best results from recent clinical trials is to slow cognitive decline rather than stop the decline or improve cognition.
Each Alzheimer’s patient has their own unique set of triggers that must be identified and addressed.

What is the current Alzheimer’s Disease Treatment today?

Treatment of AD can be challenging. Conventional treatment strategies for Alzheimer’s Disease have been almost completely unsuccessful. The best results from pharmaceutical drug trials show that the rate of progression in cognitive impairment slows down (Toups K, 2022). But there is unfortunately no improvement or stabilization in cognition (Toups K, 2022).

One reason that conventional medicine has no effective treatment for Alzheimer’s is that there is no agreement on the cause of Alzheimer’s. There are various theories of the cause, including (Toups K, 2022):

Alzheimer’s Disease is Type 3 Diabetes
AD is due to chronic Herpes simplex infection
AD is due to amyloid beta plaque in the brain
AD is due to misfolded and abnormally shaped Tau protein in the brain

Narrowing in on and treating for one of these ‘causes’ is ineffective. It does not target the underlying root causes. It instead tries to address common secondary factors, such as amyloid plaque in the brain.

Fortunately, we have Functional Medicine!

There are a number of approaches to take with AD, depending on the root cause(s). Our Functional Medicine (FM) clinic is well-versed in addressing and treating Alzheimer’s. In our clinic, we know that early-stage dementia can be addressed. Later stage dementia can also be helped significantly by a FM approach.

FM gives us a more effective strategy than the current drug therapy, which doesn’t work. A new study looking at early-stage Alzheimer’s Disease using a FM approach proves our point (Toups K, 2022):

In people who followed a detailed and individualized FM protocol, 84% showed improved cognition.

What is the FM approach and how does it help with AD?

An effective FM approach to dementia is to identify the root cause(s) of cognitive decline in each patient and address them one by one.

What are the Potential Root Causes or Triggers that can contribute to AD?

The factors that can potentially contribute to dementia and eventually Alzheimer’s include (Toups K, 2022):

Inflammation
Insulin resistance
Protein glycation: Protein glycation is a reaction between sugars and proteins. It is involved in the pathology of diabetes and neurodegenerative disease. Glycation end-products are present in the brain areas affected by Alzheimer’s Disease.
Vascular disease: Blood vessels carry oxygen and nutrients throughout the body and remove waste from tissues. Common vascular problems happen because plaque (made of fat and cholesterol) slows down or blocks blood flow inside arteries or veins.
Nocturnal hypoxemia: Hypoxemia is when oxygen levels in the blood are lower than normal and can lead to a lack of oxygen in the body’s organs and tissues. If blood oxygen levels are too low, hypoxemia can lead to mild symptoms (headaches, shortness of breath). In severe cases, hypoxemia can interfere with heart and brain function.
Hormone insufficiency or dysregulation
Nutrient deficiencies
Dysbiosis of the gut microbiome
Specific pathogens
Toxin exposure
Biotoxins
Chronic infection
Genetics

If these factors can be addressed with an individualized protocol for cognitive decline, then dementia can be slowed down, improved and even reversed, depending on the individual case (Toups K, 2022).

The recently published study which found improvement in 84% of participants, followed FM principles (Toups K, 2022). This study basically encompasses everything taught in our online FM school/program.

If you want an overview of FM principles, please look at our blog here. For an explanation of how FM differs from conventional medicine see our blog here.

In the study, researchers looked at the following issues linked to Alzheimer’s Disease-related cognitive decline: (Toups K, 2022):

Insulin resistance / sensitivity
Hyperlipidemia / high cholesterol
Inflammation
Pathogens
Blood oxygenation, cerebral blood flow, ketone availability and mitochondrial function
Hormones and nutrient levels
Autoimmunity
Toxin build-up

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Treatment

Researchers also looked at the Alzheimer’s patients’ lifestyle choices and optimized these where needed:

Diet

The diet used in the study is one we advocate in our practice. It was high in fiber, with lots of vegetable, leafy greens and other non-starchy vegetables (both raw and cooked). It was mildly ketogenic (i.e., low carb) diet, high in unsaturated fats, low in glycemic load. Participants had a nightly fasting period of 12–16 hours. They ate organic vegetables, wild-caught low-mercury fish (salmon, mackerel, anchovies, sardines, herring), pastured eggs and meats. Importantly, the diet removed processed food, simple carbohydrates, gluten-containing foods and dairy.

Exercise

Participants exercised for at least 45 minutes / day, at least 6 days per week (for aerobic exercise) and at least twice per week (for strength training). High-intensity interval training (HIIT) was recommended for a minimum twice / week.

Sleep

The study included sleep hygiene to make sure participants had 7-8 hours of quality sleep per night. People were tested for sleep apnea and were given a CPAP machine, if necessary, to improve sleep.

Stress

Stress management was done for a minimum of 10 minutes per day, using biofeedback and heart-rate variability training.

Brain exercise

Brain training was done for a minimum of 15 minutes / day. Participants performed 29 cognitive exercises that target speed and accuracy of information processing.

Other health factors were looked at and corrected if necessary:

Hormones

For study participants with hormonal imbalances, bio-identical hormone replacement and supplements were given. The goal was to optimize sex hormone levels, DHEA, pregnenolone and vitamin D. Thyroid medication was used for people with low thyroid or thyroid dysfunction. Patients with nutrient deficiencies were given the appropriate nutrients such as vitamin D, omega-3, B vitamins, CoQ10 or minerals.

Gut health

Some people in the study had gastrointestinal hyperpermeability, infections, inflammation or impaired absorption / digestion. These people went through a gut healing protocol with dietary restrictions, gut-healing nutrients, digestive enzyme support and treatment of any identified dysbiosis.

Inflammation

People were identified for systemic inflammation. They were given supplement support and anti-inflammatory herbs, such as liposomal glutathione, fish oil, resveratrol, vitamins C and D, Boswellia, quercetin and omega-3 fats. In some cases, low-dose naltrexone was prescribed. Patients who showed cognitive improvement at 6 months but still had residual systemic inflammation went on the Fasting-Mimicking Diet to reduce inflammation.

Chronic infection

Any infection linked to cognitive decline or systemic inflammation was identified. For example, people with Herpes simplex infection or a history of outbreaks, took the medication Valacyclovir for 2–6 months. Active Epstein-Barr Virus was treated with herbal protocols (Juniperus, Acer and Tamarix). People with tick-borne infections, such as Borrelia, Babesia or Bartonella, took herbal anti-microbials, such as Japanese knotweed along with immune support.

Toxicity

People who had toxicity from metals (mercury or lead), organic pollutants (benzene, phthalates, or organophosphate insecticides) or biotoxins (trichothecenes, ochratoxin A, or gliotoxin) were treated. A targeted detoxification protocol using binding agents (Cholestyramine or bentonite clay), sauna, herbs, sulforaphane and avoiding seafood if necessary (Toups K, 2022).

Testing

It is important to utilize testing of various types to assess for cognitive decline and to track improvements or decreases in cognition. This way, the FM practitioner knows where you are, if you need treatment and how treatment, or even lack of treatment, is affecting cognition.

As part of the FM treatment approach to Alzheimer’s, we run lab tests at the start of treatment. These lab tests need to also be run at regular intervals, say every 6-12 months, to track progress. The tests will help to identify issues contributing to or causing Alzheimer’s, such as insulin resistance; inflammation and infections; hormone or nutrient imbalances; and toxic load (chemical, biological or physical).

Specific issues or potential root causes to look for through lab testing are:

A genetic tendency towards dementia via the ApoE4 gene status
Underlying infection such as Lyme Disease, a Lyme co-infection, mold disease or CIRS, viral or bacterial infection or MARCoNS staph infection
Neurological antibodies that may indicate the presence of neurological diseases
Detoxification ability: Glutathione and liver function
Insulin resistance: Hemoglobin A1c, Fasting Insulin, Fasting glucose
Cholesterol levels: Total Cholesterol, HDL, Triglycerides, LDL, Cholesterol/HDL Ratio, Non-HDL Cholesterol
Complete Metabolic Panel to monitor liver and kidney health, blood protein levels and metabolism
Complete Blood Count to monitor overall health, including potential for anemia, infection and leukemia
Inflammation: Hs-CRP (high sensitivity C-reactive protein)
Hormone status: Estradiol, DHEA-S, Total Testosterone, Free T3, Reverse T3, Free T4, TSH, Progesterone, Cortisol
Nutrient status: Vitamin D, Vitamin B12, Folate, Vitamin E, Vitamin A, Serum Zinc, Serum Copper, Ferritin
Heavy Metals Panel: mercury (Hg), lead (Pb), arsenic (As)
Gut infections or overgrowths or dysbiosis via the SIBO breath test and GI Maps stool test

In addition to blood markers, if you are concerned about cognitive function, it is important to monitor and track status, for which there are a number of tests that can be done online. Re-testing helps to track if cognitive performance declines over time or improves with treatment.

The tests to consider can be found at the following links:

The Results of the FM Approach

The positive results from this study are very encouraging. The treatment targets biochemical pathways associated with cognitive decline. The results show that some of the biochemical targets addressed are causal. And that targeting some of these pathways can impact the causes of cognitive dysfunction (Toups K, 2022).

In this study, there were no serious adverse events recorded. Most patients improved their overall health on this protocol. Some no longer need blood pressure meds, anti-diabetes drugs or statins. This is because each person’s root causes of poor health were targeted to address cognitive decline, improve resilience and increase overall health (Toups K, 2022).

The study did not look at patients with intermediate or advanced stage Alzheimer’s Disease. Later-stage AD can be more challenging. But there are anecdotal reports of patients with more advanced dementia showing improvement with a similar FM approach (Toups K, 2022).

Summary

Alzheimer’s Disease is a difficult to treat illness and pharmaceutical treatment has provided minimal benefit. Functional Medicine is an alternative approach to treating AD that has shown encouraging results by utilizing a multifactorial, root-cause approach. Potential lifestyle treatments include:

Sleep optimization: at least 7-8 hours per night
Diet: High in fiber, vegetables, leafy greens, and other non-starchy vegetables. Mildly ketogenic and high in unsaturated fats
Exercise: At least 45 minutes/day 6 days/week (aerobic), twice/week (strength), twice/week (HIIT)
Stress management: 10 minutes/day
Brain training exercises: 15 minutes/day
Hormone optimization through supplements and hormone optimization as needed
Treatment of gut disorders through a gut healing protocol
Inflammation modulation though comprehensive supplementation
Addressing chronic infections: Addressing chronic infections as needed
Reducing toxic burden through detoxification protocols

Although there is no cure for Alzheimer’s Disease, lifestyle factors are showing promise in slowing and potentially reversing cognitive decline through comprehensive personalized protocols. As further root causes are identified, it will be interesting to see what the future of FM treatment of dementia will bring.

Our functional medicine clinic is extremely well-versed in addressing and treating Alzheimer’s. In our clinic, we address potential root causes. In our online Functional Medicine program, you will learn how to identify the various root causes of cognitive impairment and Alzheimer’s and how to implement these treatments to improve your patients’ lives.

** Please stay tuned for our next Blog! **

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