Peptide Therapy: KPV: The Anti-Inflammation & Pro-Healing Peptide


Next in our Peptide Series, we take a look at a new peptide: KPV. Like other peptides, it can provide a novel remedy to health issues. KPV is especially good for fighting inflammation, healing wounds and resolving gut issues. Please read on for the details!

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We have recently written many blogs about peptides. To recap, a peptide is a small protein, made up of a chain of amino acids. They can be used therapeutically to help with different health conditions. Click on the links to see our articles on peptide therapy, HGH, CJC 1295/Ipamorelin, BPC 157, PT 141, Ta1, VIP and Thymosin Beta 4.

What Is KPV?

KPV is a peptide that is naturally produced in the body. It is found in the hormone alpha-MSH. It is used for inflammation, gut health and conditions such as Inflammatory Bowel Disease (IBD) and colon cancer.

What are the Benefits & Applications of KPV?

  • Anti-inflammatory
  • Anti-microbial
  • Used in healing wounds & injuries
  • Helps with Inflammatory Bowel Diseases (IBD) and colitis
  • Some benefits with cancer


KPV exerts its anti-inflammatory function inside cells, where it inactivates inflammatory pathways (Xiao B, 2017). KPV enters the cell and interacts directly with inflammatory signalling molecules inside the cell (Land, 2012). It enters the nucleus of the cell and, once there, can inhibit the interaction of inflammatory substances and molecules (Land, 2012).


In addition to its anti‐inflammatory effect, KPV also has antimicrobial effects against pathogens (Luger TA, 2007). Its antimicrobial effects were demonstrated on two major pathogens called S. aureus and C. albicans (Böhm M, 2019). In one study, KPV significantly inhibited S. aureus from forming colonies (Böhm M, 2019). 

Wound Healing

Research in wound healing shows KPV can speed wound healing, reduce infection, fight inflammation, and lead to better cosmetic results (Böhm M, 2019). Often with wounds, various microbes enter the wound. KPV, with its anti-inflammatory and anti-microbial properties, can be very helpful for combatting these microbes and healing wounds (Böhm M, 2019).

Gut Issues: Ulcerative Colitis & Inflammatory Bowel Diseases (IBDs)

KPV significantly decreased inflammation in colitis (Dalmasso G, 2008). It decreases the inflammatory response by inhibiting proinflammatory cytokine (molecule) synthesis and secretion (Dalmasso G, 2008). KPV can stop the proinflammatory mechanisms in both intestinal epithelial cells and immune cells (Dalmasso G, 2008). It can interact directly with immune cells which can reduce inflammation (Dalmasso G, 2008). KPV may help in the case of IBDs through inhibited immune responses (Dalmasso G, 2008).

Taken orally, KPV reduces the incidence of colitis, as shown by a decrease in proinflammatory cytokines (Dalmasso G, 2008). In the case of colitis, KPV reduced weight loss, colonic activity and decreased inflammation and proinflammatory cytokine levels (Dalmasso G, 2008).


KPV treatment is able to decrease tumorigenesis (Viennois E, 2016). KPV was sufficient to decrease the inflammation of carcinogenesis (Viennois E, 2016). Using KPV before the development of colon cancer might be a preventive way to stop colonic carcinogenesis before it begins (Viennois E, 2016). The precise mechanism by which KPV decreases tumorigenesis is not yet fully understood (Viennois E, 2016).

Method of Delivery for KPV

Iontophoresis is method of taking medications. KPV is often taken via this method. It uses low-level current to drive charged compounds across the skin barrier (Ita, 2016). Iontophoresis is very useful because it increases the absorption of drugs and is a way of driving KPV, or another drug, deeper into the skin, bypassing the first metabolism in the gut (Rawat S, 2008).

Side Effects

KPV is a naturally derived peptide without any notable side effects (Xiao B, 2017). KPV has been shown in animal studies to be safe and effective when administered orally, intravenously, subcutaneously and transdermally (Xiao B, 2017).

There is always the chance of potential interactions with other medications a person may be taking. It is very important to work with an experienced Functional Medicine practitioner when taking KPV or any other peptides. Our clinic has extensive experience with peptides and can help you with KPV or other peptides.

**Please stay tuned for our next blog on more Peptide Therapy!**

As always, please get in touch with us. If you or someone you know is struggling with inflammation, gut issues, chronic disease or general health issues, contact our clinic today. If you are interested in functional medicine training, please schedule a free practice evaluation call with us to see if our online functional medicine training and mentorship program meets your needs. 

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Dr. Miles Nichols and Dr. Diane Mueller have spoken for the following organizations:

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